Cannabis or Marijuana is one of the most used, abused, and produced recreational substitutes worldwide. According to trusted sources, about fourteen million people are only in the Us, and about 2.5 percent of the population uses cannabis. The numbers are growing gradually with time, not decreasing at all. Marijuana was a potent medical invention at first. Medical professionals intended to use it for pain management and geriatric care. Palliative care is very tough with most medicines and does not work well. Cannabis was a breakthrough invention for people in need. But, soon, people found out the solid recreational and intoxicating properties of cannabis. It did not take long for the producers and suppliers to sell cannabis in the open market for extra money.
As cannabis has some medicinal value, it took over the drug market from other substances very quickly. To date, no government could get a hold on the cannabis trade worldwide. So, Canada, Uruguay, the USA, and most other countries are desperate to legalize cannabis ingestion. It will at least help the narcotic officials to get a hold on the sales and production. Also, an eligible age to buy and trade cannabis can reduce drug intoxication by many folds in society.
Mechanism of acute intoxication
Shockingly, cannabis can produce a very high intoxication within minutes of ingestion. Different strains have several routes of introduction. Inhalation is the fastest way to produce intoxication. In contrast, ingestion keeps the recreational state intact for more extended periods. The trick lies in the mechanism of action of cannabis. Cannabis has several ingestible strains. But, most people use cannabis Sativa as a dried flower to inhale. Cannabis indica is also a very famous strain to produce strong intoxication.
Cannabis works as a G protein-coupled receptor. It works by binding with the adenylyl cyclase enzyme. This adenylyl cyclase inhibits the coupling of actin and myosin fibers. It is by the formation of adenosine monophosphate. Usually, we use the triphosphate form of adenosine to produce energy and maintain biological functions. This process also improves potassium influx within the cells. Altogether, it helps our central and peripheral nervous systems to relax. Cannabis has two receptors for extensive function throughout the body. The CB1 receptor is available in the central nervous system, basal ganglion, and nigrostriatal system. Also, The peripheral immune organs, like the spleen, the reticuloendothelial system, contains the CB2 receptor.
By now, we understand the mechanism of action of cannabis. Most people use the dry flowers or crushed seeds of Cannabis Sativa. Nowadays, there are two strains available in the countries which legalized cannabis. One is the prescription strength that you can only get in the hospital’s under-trained physicians. Non-prescription strengths are available as over-the-counter drugs. It works wonders for headaches, chronic pain, and such problems.
The highest THC strains can produce effects within two minutes. The effects can last up to two hours. Tetrahydro cannabinoids or THC is the most potent strain of cannabis. It can activate and produce signs with only 30 ml of lung volume, and two to three grams are more than enough in the inhalation route to act. Ingestion can take a little longer than it. Cannabis Ingestion takes about half an hour to fully onset the symptoms. But, it is the long-lasting option that people with chronic pain usually prefer. There are many recipes for taking cannabis or cannabinoid products. You can make tea, juice, or smoothie with a bit of infusion of cannabis Sativa, and it will give you a heavenly feeling. Make sure that you are taking a safe amount each time.